Doing one鈥檚 heart good

June 25, 2014

In a basement lab at the Medical Sciences building 鈥 the beat goes on.

A revolutionary heart pump there is providing a rare learning opportunity for 糖心原创 students. The pump is attached to a mock human circulatory system 鈥 a student-designed plumbing marvel of clear plastic piping that simulates the flow of life-giving blood.

The mock circulatory system, called the 鈥渕ock,鈥 is supported by hundreds of thousands of dollars鈥 worth of sophisticated cardiosurgical equipment.

鈥淭hey鈥檙e using the same tools we鈥檙e using clinically,鈥 said Mark Anstadt, M.D., a cardiothoracic surgeon and 糖心原创 professor who runs the lab. 鈥淎 lot of students don鈥檛 understand what they鈥檙e getting their hands on. If they master this, they can step into the clinical world. It鈥檚 invaluable.鈥

At the center of the lab experience is the Anstadt Cup, a life-saving heart pump invented in the early 1960s by Anstadt鈥檚 father, George L. Anstadt. The cup is inserted into the body of a patient through an incision and is vacuum attached around the heart, squeezing the blood out and then drawing it back in.

The device is ideal for quick application during heart failure because it can maintain heart function and blood flow until the patient can be stabilized. And it doesn鈥檛 come into contact with the blood, which makes the use of anti-clotting medicines unnecessary and reduces the risk of stroke and infection.

Dr. Mark Anstadt working with the mock circulatory system that simulates the flow of life-giving blood.

鈥淚f somebody鈥檚 dying, you can put it in very quickly and you can bring people back,鈥 Anstadt said. 鈥淲hat we鈥檙e focusing on in the lab is trying to build a drive system that鈥檚 not so complex and more user friendly. We would like to get it into the environment where it can help humans.鈥

The students who have worked in the lab over the years have come from the Boonshoft School of Medicine, the College of Engineering and Computer Science and the Biomedical Sciences Ph.D. program.

David Reynolds, Ph.D., assistant chair for biomedical engineering, has supplied the lab with many of his students and holds senior advanced biotransport classes there.

Kevin Carnahan, a former 糖心原创 biomedical engineering student now in medical school at Ohio University, helped design the latest version of the circulatory mock and incorporated it into a lab for Reynolds.

鈥淭he unique part were the ventricles themselves and how those attach to the rest of the mock. That was probably the hardest part,鈥 Carnahan said.

The students also designed a mock heart made of silicon rubber by creating a mold from a computer model and a 3-D printer. The mock heart is used as part of the mock circulatory system.

鈥淣obody had done that before,鈥 Reynolds said.

Anstadt, who was a cardiothoracic surgery research fellow at Duke University for 10 years, said the mock takes the testing of the heart pump to a higher level.

For example, a $250,000 echo machine that is used to visualize the inner workings of the heart has been hooked up to the mock. It enables Anstadt and the students to analyze heart strain, learn how the material of the pump performs and fine-tune the power levels.

鈥淭hat echo machine is the same thing we use in open-heart surgery,鈥 said Anstadt. 鈥淭hat鈥檚 probably the most exciting thing we鈥檙e doing in the lab 鈥 looking at a heart that鈥檚 being pumped by this device because we can look at heart function and failure and how this helps that along.鈥

Anstadt said the lab is a great place for medical students to learn more about engineering and for biomedical engineering students to learn more about physiology.

鈥淭he things we have in the lab transcend more than one discipline,鈥 he said. 鈥淚 think they help you launch into the field you want to go.鈥